Scientists from Colorado State University have found that African clawed frogs (Xenopus laevis) exposed to very low concentrations of di-n-butyl phthalate
(DBP) suffered numerous problems .
In a river of Aomori Prefecture, the concentration of di-n-butyl phthalate
, used for plastic processing, was close to the level that could harm fish, the study showed.
Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate
in fetal rat testis.
On average, those men had 33% higher urinary concentrations of a metabolite of di-n-butyl phthalate
(DnBP) than men with two functional FLG copies.
Phthalate Parent phthalate diesters group LMW DEP Diethyl phthalate MEP DnBP Di-n-butyl phthalate
MnBP DiBP Diisobutyl phthalate MiBP BBzP Butylbenzyl phthalate MBzP HMW DEHP Di(2-ethylhexyl) phthalate MEHP MEHHP MEOHP MECPP DOP Dioctyl phthalate MOP MCPPS DiNP Diisononyl phthalate MiNP MHiNP MOiNP MCiOP Phthalate Measurable urinary metabolites LOD group (ng/mL) LMW DEP Monoethyl phthalate 0.
Low-molecular-weight phthalates, such as diethyl phthalate (DEP), di-n-butyl phthalate
(DnBP), and diisobutyl phthalate (DiBP), are used in personal care products, solvents, adhesives, and medications [Kelley et al.
Low-molecular-weight (LMW) phthalates (diethyl phthalate, di-n-butyl phthalate
, di-n-octylphthalate and di-n-isobutyl phthalate) are predominantly used in shampoos, cosmetics, lotions and other personal care products to preserve scent (Hauser and Calafat 2005; Sathyanarayana 2008; Sathyanarayana et al.
Both di-n-butyl phthalate
(DBP) and di-(2-ethyl-hexyl) phthalate (DEHP) are examples of such phthalates; these phthalates are chemically and toxicologically distinct from diesters of isophthalic or terephthalic acids, which are not considered to be true "phthalates," as defined by the U.
Diethyl phthalate (DEP), di-n-butyl phthalate
(DBP), and benzylbutyl phthalate (BzBP) can be used in personal care and consumer products to hold scent and color [National Research Council (NRC) 2008].
The authors report that labeling information for 6 RX drug products included di-n-butyl phthalate
(DBF) as an excipient and 45 labels specified diethyl phthalate (DEP).
Experimental research is limited hut has shown adverse effects of prenatal exposure of rats to di-2-ethylhexyl phthalate (DEHP) and di-n-butyl phthalate
(DnBP) on pup learning, memory, and behavior (Arcadi et al.
Diverse developmental toxicity of di-n-butyl phthalate
in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation.