Peng, "Biodegradation of di-n-butyl phthalate
and expression of the 3,4-phthalate dioxygenase gene in Arthrobacter sp.
Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate
in utero and during lactation and determination of its NOAEL.
Highest level of Di-n-butyl phthalate
(DBP) and Butylbenzyl phthalate (BBP) ) in fish samples was found in Tilapia and Bluefish as (1.09(Mu)g g [?]1 ) and (1.81 (Mu)g g [?]1 ) while in shellfishery Clam and Oyster were contaminated at maximum level of (2.00 (Mu)g g [?]1 ) and (1.56 (Mu)g g [?]1 ) respectively.
BHA, butyl benzyl phthalate (BBP) and di-n-butyl phthalate
(DBP) not only appeared estrogenic, but also stimulated the growth of breast cancer cells in culture, the group reports in the June Environmental Health Perspectives.
The three phthalates most commonly used in personal care products are diethyl phthalate (DEP), which is found in scented products, including perfumes, deodorants, soaps, and shampoo; and di-n-butyl phthalate
(DnBP) and di-isobutyl phthalate (DiBP), which are used in nail polish and cosmetics (Dodson et al.
Chronic di-n-butyl phthalate
exposure in rats reduces fertility and alters ovarian function during pregnancy in female Long Evans hooded rats.
Exposure of human fetal testis xenografts to di-n-butyl phthalate
. J Clin Endocrinol Metab 97(3):E341- E348 (2012); doi: 10.1210/ jc.2011-2411.
We agree that the downward trend in exposures to phthalates such as di-n-butyl phthalate
(DnBP) and di(2-ethylhexyl) phthalate (DEHP) is encouraging, but the rising trend in other phthalates, such as diisobutyl phthalate (DiBP) and diisononyl phthalate (DiNP), is worrisome.
Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate
in fetal rat testis.
On average, those men had 33% higher urinary concentrations of a metabolite of di-n-butyl phthalate
(DnBP) than men with two functional FLG copies.
Low-molecular-weight phthalates, such as diethyl phthalate (DEP), di-n-butyl phthalate
(DnBP), and diisobutyl phthalate (DiBP), are used in personal care products, solvents, adhesives, and medications [Kelley et al.
Low-molecular-weight (LMW) phthalates (diethyl phthalate, di-n-butyl phthalate
, di-n-octylphthalate and di-n-isobutyl phthalate) are predominantly used in shampoos, cosmetics, lotions and other personal care products to preserve scent (Hauser and Calafat 2005; Sathyanarayana 2008; Sathyanarayana et al.