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References in periodicals archive ?
Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity.
13-16 h]]) from highly synchronous cultures were exposed to 700 nmol/L dihydroartemisinin or 0.
The blood concentrations of artesunate and dihydroartemisinin may have been 20% lower than ideal (as predicted by a pharmacokinetic model), but this finding cannot explain why the parasite density remained >200,000/pL for several days.
2002), and the artemisinin derivative dihydroartemisinin targets human metastatic tumor cells (Cabello et al.
Antifertility Activity Of Dihydroartemisinin In Male Albino Rats.
At day 6 of hospitalization, artesunate and clindamycin were discontinued, and oral treatment with dihydroartemisinin (40 mg/tablet)/piperaquine (320 mg/tablet) was administered through a nasogastric tube for 3 days (4 tablets/day the first day, then 2 tablets/day).
579), but a significant association was found for dihydroartemisinin (p = 0.
The availability of counterfeit artesunate and counterfeit dihydroartemisinin has also been reported in Cameroon and Tanzania (12).
Deoxyqinghaosu, dihydroartemisinin, 3-desoxy- and arteannuic acid were proved to be present only in A.
Because dihydroartemisinin has a short half-life (26), prolonged hemolysis after stopping treatment with IV artesunate and the recurring hemolysis in 2 patients suggest that a direct hemolytic effect of the drug is unlikely, although contaminants may have a longer half-life.
The studies were designed to compare the safety and efficacy of the combination of dihydroartemisinin and piperaquine (DHA/PQP) to the ACTs artemether/lumefantrine (in Africa) and artesunate+mefloquine (in Asia).
Artesunate is an antimalaria agent and a hemi-succinate derivative of dihydroartemisinin.