Different contact allergens like dinitrochlorobenzene (DNCB), squaric acid dibutyl ester (SADBE) and diphenylcyclopropenone
(DPCP) can be used.
According to the company, Samcyprone is a proprietary topical formulation of the small molecule diphenylcyclopropenone
(DPCP), a topical immunomodulator that works by initiating a T-cell response.
This study evaluated the safety and effectiveness of Samcyprone, a proprietary topical formulation of the small molecule diphenylcyclopropenone
, for the treatment of common warts.
Aghaei evaluated the efficacy of diphenylcyclopropenone
in the treatment of severe alopecia areata, observing that salmon patch was present in 40.7% of the patients, whereas nail involvement (already known to be associated with a worse prognosis) was seen in 59.3% and thyroid diseases in 11.1%.
Contact immunotherapy with diphenylcyclopropenone
(DPCP) or squaric acid dibutylester (SADBE) is also recommended for severe AA.9-11 Hair regrowth occurs in about 50% of cases but response rate is much lower in patients with AT and AU.
A team led by Professor Neil Walsh, Director of the Extremes Research Group in the School of Sport, Health & Exercise Sciences at Bangor University administered a chemical called diphenylcyclopropenone
(DPCP) through a patch on the lower back, 20 minutes after exercise bouts of various lengths and intensities.
Later, potent contact allergens namely dinitrochlorobenzene (DNCB) and diphenylcyclopropenone
(DPCP) replaced the allergens that were used earlier (33).
Topical immunotherapy (squaric acid dibutylester [SADBE] and diphenylcyclopropenone
[DPCP]) induces the most significant short-term hair regrowth in children with severe AA (strength of recommendation [SOR]: C, 4 small individual cohort studies and 1 moderately sized retrospective case review).
Topical sensitizers, such as squaric acid dibutylester (SADBE) or diphenylcyclopropenone
(DPCP), can be rubbed on the scalp, creating an allergic response and resulting in hair growth, Dr.
Samcyprone, a proprietary topical formulation of the small molecule diphenylcyclopropenone
(DCPC), is a topical immunomodulator that works by initiating a T-cell response.
A large variety of therapeutic modalities have been suggested for the treatment of AA, which include topical steroids, contact sensitizers such as dinitrochlorobenzene, squaric acid dibutylester and diphenylcyclopropenone
or a tacrolimus, anthralin, nitrogen mustard or minoxidil.
The product is an immunomodulating topical gel containing the active agent, diphenylcyclopropenone
, developed by Hapten.