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References in periodicals archive ?
Thus, their results suggested that polyphenolic compounds might be potential structural bases and source to find and project nature-based, safe, orally bioavailable direct thrombin inhibitors.
Ciraparantag binds directly to factor Xa inhibitors, dabigatran, LMWH, and unfractionated heparin and is under evaluation for reversal of both direct thrombin inhibitors and factor Xa inhibitors [51].
Van Cott et al., "Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage," Circulation, vol.
Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate.
(3) Direct thrombin inhibitors (Parenteral): These drugs are especially useful in cases of heparin induced thrombocytopenia (HIT).
Haertter et al., "Dabigatran etexilate- A novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity," Journal of Thrombosis and Haemostasis, vol.
No other agent is approved for patients with HIT who are undergoing angioplasty, but argatroban and other direct thrombin inhibitors have been used off-label for this indication, he noted.
ANGIOMAX is a small-molecule, reversible, direct thrombin inhibitor that has been shown to reduce the incidence of death, myocardial infarction, and the need for revascularization in patients undergoing balloon angioplasty.
* Direct thrombin inhibitor. Management of direct thrombin inhibitors (dabigatran) is also dependent on surgical bleeding risk and renal function (table 3).
The HemosIL Rivaroxaban Testing Solution is the second assay IL has commercialised in the company's DOAC Assay Panel, following the introduction of their HemosIL Direct Thrombin Inhibitor Assay for measurement of dabigatran (Pradaxa) in September 2014.
Bivalirudin for injection is a direct thrombin inhibitor indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA), undergoing percutaneous coronary intervention (PCI) with provisional use of glycoprotein IIb/IIIa inhibitor (GPI) and heparin-induced thrombocytopenia (HIT) or heparin-induced thrombocytopenia and thrombosis syndrome (HITTS) undergoing PCI, concluded the company.
Dabigatran is a direct thrombin inhibitor that is currently FDA approved to reduce stroke and systemic embolism risk for patients with nonvalvular atrial fibrillation.