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DMT IDivalent Metal Transporter (protein)
DMT IDiabetes Mellitus Type 1
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References in periodicals archive ?
The three groups did not differ significantly with regard to cellular HEPH and divalent metal transporter 1 (DMT1) expression.
(a) Significant p value between DM and control; Significant p value between control and DM + anemia; (b) significant p value between DM and DM + anemia; DM: diabetes mellitus; FPN: ferroportin; HEPH: hephaestin; DMT1: divalent metal transporter 1; TfR: transferrin receptor.
Western blots of BM, spleen, and monocytes/macrophages lysates (50 [micro]g) for Cleaved Caspase-3 (5A1E, Cell Signaling), Bcl-[x.sub.L] (H-5), divalent metal transporter 1 (DMT1) (H-108), Fpn1 (G-16), Tfr2 (S-20), [beta]-actin (C-4) (Santa Cruz Biotechnology), and Ft-L (kindly provided by S.
Thus, it could be interesting to further investigate the relationship between Tfr2[beta] and this divalent metal transporter.
Another study reported that divalent metal transporter 1 (DMT1) + IRE upregulation is involved in 6-OHDA induced iron accumulation and aggravated oxidative injury [36].
Lead, cadmium and arsenic are some of the common industrial environmental pollutants in Pakistan.Lead enters placenta during pregnancy via dust, polluted food and water (Hubermont et al.1978; Carrington et al., 1993), by simple diffusion, (Georgieff et al., 2000) facilitated by divalent metal transporter 1 (DMT1) which has high affinity foriron and lead (Gunshin et al., 1997) and is present in cytoplasm and membrane of syncytiotrophoblast since 8th gestation week (Georgieff et al., 2000).
For example, the divalent metal transporter (DMT1, DCT1, and Nramp2) transports divalent metals, but not metals in other valence states.
Increased activity of an iron transporter, called divalent metal transporter 1 (DMT1) protein, has been demonstrated to cause beta cell damage by increasing intracellular iron-levels.15 This too, may be a potential therapeutic target in selected patients.
(9) Following reduction, the [Fe.sup.2+] becomes a substrate for the divalent metal transporter DMT1.
The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in Caenorhabditis elegans models of manganism and Parkinson disease.
Fe(II) is transported across the cellular membrane by a 12-transmembranesegment protein, divalent metal transporter 1 (DMT1), also known as SLC11A2, NRAMP2 and DCT1 (Table I).