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References in periodicals archive ?
A high therapeutic index opioid : Because ARX-01 uses the high therapeutic index opioid sufentanil, it offers post-operative pain patients the potential for effective patient-controlled analgesia with a low incidence of drug-related side effects. Published data on IV PCA side-effect profiles suggests that somnolence (~50% of patients) and oxygen desaturation (~10% of patients) is unacceptably high.
"Successfully completing phase 1a demonstrates that the drug is safe, with no drug-related side effects at all in a single dose of 100mg.
The guide includes case studies, a practice exam with an answer key, and appended information on common drug-related side effects.
The most commonly reported drug-related side effects in the colesevelam patients were constipation in 7% and dyspepsia in 3%.
On the other hand, he adds, both drug companies and patients would benefit from genetic tests that flag people--of any race--most likely to suffer drug-related side effects. In the case of the HIV drug efavirenz, for example, doses could be adjusted for the whites, as well as for the blacks, who have the genetic trait that's been associated with problems.
Lower drug use potentially makes treatments more cost-effective and lessens the chance of drug-related side effects. The study was published online in the American Society for Artificial Internal Organs Journal.
Discovered by AstraZeneca, AZD5213 has been shown to have a favorable safety profile, with no serious drug-related side effects reported in Phase 1 and Phase 2 clinical trials completed at the time of this report.
The most common drug-related side effects are grade 1-2 fever and mild flu-like symptoms, which can be prevented with standard medications, Niiki said, adding that the maximum tolerated dose has not been reached and NKP-1339 dose escalation continues.
For the human study of the drug, the researchers reported that in a phase 1 clinical trial of 48 healthy normal-weight adults, the drug was well tolerated even at the highest dose, with seven of the volunteers experiencing brief, mild drug-related side effects such as abdominal discomfort, nausea and diarrhoea.
Particularly impressive was the fact that there were essentially no drug-related side effects, Dr.
That strategy minimized patients' risks of drug-related side effects, including heart-threatening jumps in body fat.
Various methods of androgen suppression yield similar survival rates, but orchiectomy is cheaper and spares patients repeated hospital visits and drug-related side effects. But orchiectomy is unacceptable to many men, and the patient's preference should drive the selection of antiandrogen therapy, they said.