E-CTCExportable Combat Training Centers (US DoD)
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As shown in Figure 3, E-CTCs were detected in all patients regardless of the presence or absence of lymph node metastases; however, M-CTCs and CTMs were detected in significantly more patients with lymph node metastasis than without.
Furthermore, it was discovered that MCTCs and CTMs were most common in patients with advanced cancer, whereas the CTMs were strongly positive for mesenchymal markers and were absent from the samples containing predominantly E-CTCs from patients with earlystage cancer.
In the present study, we also found that E-CTCs and CTMs were negatively correlated with lymphocyte counts and that the patients who were positive for E-CTCs and CTMs had significantly lower circulating lymphocyte counts than did the CTC-negative group or the group lacking E-CTCs.