E-LDLEnzymatically Degraded Low-Density Lipoprotein
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Among all tissues examined in this study, high ABCA1 mRNA expression was identified in the liver, placenta, small intestine, and stomach, but the strongest expression was observed in macrophages loaded with E-LDL (Fig.
E-LDL taken up by human macrophages and smooth muscle cells contributes to the formation of early atherosclerotic lesions (15, 16, 29, 30) and up-regulates ABCA1 mRNA in macrophages and THP-1 cells.
[4] Nonstandard abbreviations: ABCA1, ATP-binding cassette transporter A1; RT-PCR, reverse transcription-PCR; M-CSF, macrophage colony-stimulating factor; E-LDL, enzymatically modified LDL; PBGD, porphobilinogen deaminase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; and Cp, crossing point.