E2-BSAE2 Conjugated with Bovine Serum Albumin
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However, E2-BSA plus BPA induced an effect equivalent to those of E2-BSA of BPA alone, indicating a lack of synergistic or antagonistic effect and likely a convergence in the activated pathways.
Furthermore, we found that BPA plus Gl also induced the same effect as each of them alone, as was the case with BPA plus E2-BSA, indicating a similarity in the activated pathways.
An unknown GPCR has been suggested to mediate the BPA-stimulated proliferation of GC-1 cells because of the suppression of the G[alpha]i/G[alpha]q inhibitor PTX and promotion of E2-BSA, an impermeable E2 conjugate.