E2FSExt2 File System
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Caption: Figure 1: An illustration of the network involving miR-17-92, E2F and Myc (a) and its abstract model (b), where P and M represent the protein module (E2Fs and Myc) and miR-17-92 cluster, respectively.
The transcription factors E2F and Myc act as tumor suppressors or oncogenes and participate in the control of cell proliferation and apoptosis [1].
Saxena, "Transcription factors LSF and E2Fs: tandem cyclists driving G0 to S?" Cell Cycle, vol.
Gaumont-Leclerc et al., "Regulation of E2Fs and senescence by PML nuclear bodies," Genes & Development, vol.
The most studied mechanism by which pRB negatively regulates the cell cycle progression involves the biding of pRB to E2F transcription factors (E2F1, E2F2, and E2F3a), which inhibits E2F-mediated expression of S phase-promoting genes, such as DNA polymerase, dihydrofolate reductase, and cdc2 [5-8].
Expression levels of cyclins (cyclins A1, A2, B1, B2, D1, D2, and F), CDKs (CDK1 and CDK2), and E2Fs (E2F1 and E2F2) increase, whereas cell cycle inhibitors (Cdkn1a and Cdkn2a) decrease in islets of betatrophin-injected mice compared to control-injected mice.
This triggers the release of E2F transcription factors and the subsequent activation and transcription of E2F responsive genes (including E- and A-type cyclins) required for cell-cycle progression.
E2Fs up-regulate expressions of genes envolved in DNA replication, DNA repair and mitosis.
En estado de reposo o al principio de G1 el Rb actua inactivando a la familia de los factores de trascripcion E2F. El complejo Rb-E2F asegura que la fase S no se inicie, porque genes cuyos productos son esenciales para las fases S y M de-penden de la actividad del E2F.
PTEN and E2Fs mRNAs were among the first validated miR-17-92 targets.
Moreover, miR-34a downregulates transcription factor E2F and upregulates p53 in several cancers such as CRC [221].
The cell cycle progression depends on the E2F transcription factor family.