(3,4) The disease often spreads diffusely within the intestinal mucosa, with or without tumefactive lesions, in a pattern that contrasts with EATL
, which is often associated with large and ulcerative tumors that may perforate the intestine.
Type 1 EATL
is associated with celiac disease and it comprises 80%-90% of cases observed in Europe.
The current third phase of the EATL
project (2013-15) aims at making the Euro-Asian overland links more operational.
Primary small intestinal lymphoma maybe broadly categorized into three groups including immunoproliferative small intestinal disease (IPSID) lymphoma, enteropathy-associated T-cell lymphoma (EATL
) and other western-type non-IPSID lymphomas.
This increased capacity of FPF to produce IL-17A in treatment-resistant RCDII may be related to the continued inflammation and risk of EATL
development, as IL-17A is involved in chronic inflammation as well as in tumour formation .
This technique has been clinically validated and shown to be superior to T-cell receptor (TCR) clonality analysis in identifying patients at risk to develop an EATL
T-cell clonal transformation is typically viewed as an initial step along a continuum leading to overt enteropathy-associated T-cell lymphoma (EATL
Of the 26 EATLs
and 14 SICUPs deployed, 15 and 10, respectively, were recovered successfully.
may show a wide morphologic spectrum, but it usually shows a range of medium and large lymphoid cells, often admixed with a mixed inflammatory infiltrate (Figure 4, A).
Myelodysplastic syndrome, myelodysplastic/ myeloproliferative neoplasm, infectious mononucleosis, type II enteropathy-associated T-cell lymphoma (EATL
), and primary cutaneous [gamma]/[delta] T cell lymphoma should also be included in the differential diagnosis.