EBNA1Epstein-Barr Nuclear Antigen 1
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With the purpose of investigating the response to both latent and lytic states of the EBV life cycle, stimulations with EBNA1 and EBV-EA/D were conducted.
Samples were stimulated with EBNA1 (5 [micro]g/mL, Escherichia coli-derived, EBV271, Prospec Protein Specialist, Ness-Ziona, Israel) and EBVEA/D (5 [micro]g/mL, Escherichia coli-derived, EBV-272, Prospec Protein Specialist, Ness-Ziona, Israel) and with staphylococcal enterotoxin B (SEB) (10 [micro]g/mL, Sigma-Aldrich, St.
Specifically, in both NPC and EBVaGC, EBNA1 can promote the decline of the promyelocytic leukemia (PML) nuclear bodies, including many regulatory proteins, by binding and modulating casein kinase 2 (CK2) or ubiquitin-specific protease 7, which in turn degrades p53 [41].
Unlike EBNA1 and EBERs, miR-BARTs are expressed at high levels only in EBV-infected epithelial cancers, but not in EBV-transformed lymphocytes [56, 76, 77], pointing out their involvement in EBV-associated epithelial cancers.
Samples were examined by ELISA (Greiner Labortechniek; Frickenhausen, Germany) coated with EBNA1 and VCA-p18 peptide using 135 single peptide (1 mg/ml) or combined peptides (1 mg/ml EBNA1 plus 0.
Most people in Southeast Asia are first infected by EBV in early childhood, reflected by a nearly 100% seropositivity for IgG to EBV VCA and EBNA1.
EBV-encoded nuclear antigen-1 (EBNA1) specific CD4+ T-cell responses from patients with MS preferentially recognize multiple epitopes within the central part of the C-terminal EBNA1 domain, compared with fewer, more restricted, epitopes in healthy EBV carriers.
36) The response to EBNA1 correlated with the number of T2 lesions (P=0.
In this situation, EBV is in type II latency, expressing additional transcripts, including three latent membrane proteins (LMP1, LMP2A, LM2B) with the two EBERs and EBNA1.
NPC has similar technical difficulties as BL, and diagnosis is usually based on histology, despite the ability to frequently detect EBV genome and EBNA1 in tumor cells.
When bound to one region, EBNA1 helps initiate replication of the viral episome and the dispersal of the two copies into the daughter cells.
Scientists have suspected that EBNA1 doesn't work alone.