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EDRN has fulfilled these expectations by establishing a process for biomarker development by using a multidisciplinary and multiinstitutional approach.
The EDRN exists today because of improvements in oncology research in the past decade that have derived from progress in bioinformatics.
The study was sponsored by the NCI's EDRN and SPORE.
C-TASC's new Bio Repository Management System (BRMS), a fully integrated module of StudyCTMSTM, will also be deployed at NYU, enabling investigators to easily manage the processing, delivery, archival and allocation of all EDRN laboratory research specimens catalogued at the study site.
Four of the grants are to institutions new to EDRN. Funding was awarded to eight Clinical Epidemiology and Validation Centers, which conduct the early phases of clinical and epidemiological research on the application of biomarkers; four Biomarker Reference Laboratories, which work to validate the biomarker tests; and one Data Management and Coordinating Center/Informatics Center, which provides logistical, informatics, and statistical development and support.
Since its inception, EDRN investigators have learned a great deal about the process of validating biomarkers for clinical use.
The findings were reported by researchers at the Michigan Center for Translational Pathology, Ann Arbor, and were supported by the National Cancer Institute's (NCI) Early Detection Research Network (EDRN).
The serum proteomic profiling method proposed for diagnosis of ovarian and other cancers (9) and criticized until an independent validation published in Clinical Chemistry, sponsored by the Early Detection Research Network (EDRN), confirmed the inability of the method to diagnose prostate cancer (10).
The need for strongly unbiased specimens in discovery is increasingly discussed in NCI's EDRN (Early Detection Research Network) and CPTAC (Clinical Proteomic Technology Assessment for Cancer) and in commentaries about methodology (4, 6, 27).
The validation process that generated these 2 reports was conducted under a rigorous system developed by the National Cancer Institute Early Detection Research Network (EDRN).
In response to such controversy and because of the desire to evaluate the potential clinical utility of such methodologies, the National Cancer Institute Early Detection Research Network (EDRN) decided that a rigorous validation study should be undertaken.
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- Edricson, Alleyne
- Edridge-Green lamp
- Edridge-Green lantern
- Edridge-Green, Frederick W
- Edridge-Green, Frederick W.
- Edris Stannus
- Edrm System
- edrophonium chloride
- edrophonium test
- EDS due to TNX deficiency
- EDS II
- EDS III
- EDS VI