The treatment of rats with EESR prior to gamma irradiation ameliorated the activity of serum CPK, LDH, as well as the level of total cholesterol, LDL-C, HDL-C, cTnI and (CK-MB).
The amelioration observed in the level of inflammatory factors in the EESR-irradiated group suggested that EESR could have potent anti-inflammatory activities.
The present study aimed to determine the protective effectof EESR bark extract on ionizing radiation-induced cardiac injury.
This ethanol extract of Symplocos racemosa (EESR) was evaporated to dryness under reduced pressure (% yield = 6% w/w) and used (Wakchaure et al., 2011).
Group I (control group), rats received orally by gastric tube an equivalent volume of distilled water (vehicle of EESR) during two weeks.
The administration of EESR before exposure to gamma irradiation significantly limits the elevation in serum TNF-a, IL-1b and IL-6 levels compared to irradiated group.
The present work documents that treatment with EESR would protect from radiation-induced cardiotoxicity probably due to its considerable antioxidant and anti-inflammatory effects.
The amelioration of the histopathological changes observed in cardiac tissues was associated with a significant improvement in oxidative stress and MDA suggesting that EESR protect cardiac tissues from radiation due to its anti-inflammatory and antioxidant activities.