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In literature, about 19% of patients with recurrent EGCT achieve long-term DFS (11% mediastinal, 30% retroperitoneal).
In summary, EGCT is a rare, but important subset of GCTs.
Kaplan-Meier curve of the overall survival (a) and disease-free survival (b), for the overall cohort and subgroups by primary site; X-axis in months; All: all patients with EGCT; CNS: intracranial primary GCT; MP: mediastinal primary GCT; RP: retroperitoneal primary GCT.
Extragonadal germ cell tumours (EGCTs) comprise a heterogeneous group of primary germ cell tumours with distinct natural history and responses to different treatment modalities.
The usual treatment for EGCTs has been platinum-based chemotherapy regimen, such as bleomycin, etoposide and cisplatin (BEP), followed by surgical resection of residual tumours, if feasible.
The objectives of our study were to evaluate patient, disease, and treatment characteristics and survival outcomes in male patients diagnosed with EGCTs in two Canadian tertiary cancer centres.
To the authors' knowledge, our study comprises the largest published Canadian cohort of patients with EGCTs to date.
Extragonadal germ cell tumours (EGCT) comprise 5-10% of all GCT , and although they are histopathologically and serologically similar to their testicular counterparts, they carry a poorer prognosis.
Haematological neoplasia were first associated with EGCT in the 1980s with many reports since [15,21].
This case supports the view that standard chemotherapy should be administered with curative intent for patients with GCT, including EGCT, and that in order to prevent opportunistic infections and maintain control of HIV, patients with HIV-disease and cancer should be managed jointly with oncologists and HIV-physicians.
Consequently, a soldier can drastically shorten the amount of confinement he actually serves by earning GCT, EGCT, and special abatement.
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