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Picornavirus IRES elements are the examples of types I and II IRESes which require eIF4G, eIF4A, and eIF3 to assemble 48S initiation complex .
On the other hand, partial silencing assays (using the knockdown plasmid, pSilencer31 (si31), and hippuristanol (eIF4A inhibitor) treatment) have demonstrated that C- and N-myc IRESes can function only in presence of the C-terminal domain of eIF4GI, eIF4A, and eIF3; This IRES does not require full-length eIF4GI or PABP .
Moreover, a recent publication from our lab suggests that the XIAP IRES does not require eIF4G, eIF4E, and eIF4A for initiation complex formation.
While it is possible for the IRES to independently interact with the 40S and 60S ribosomal subunits, canonical translation factors (e.g., eIF4A and eIF3) and IRES-transacting factors (ITAFs) are usually involved to enhance translation efficiency.
The eIF4E2 interacts with eIF4A and eIF4G3 to form a hypoxic eIF4F (eIF4[F.sup.H]) complex that increases translation efficiency independent of mRNA abundance  (Figure 1(b)).
Interestingly, eIF4A is also part of eIF4[F.sup.H], and drugs inhibiting this RNA helicase have displayed high preclinical potency, especially silvestrol, in mouse models of tumor progression .
Here we showed that CPT potentially bound to eIF4A, one of the components of eIF4F.
Targeting the eIF4A RNA helicase as an anti-neoplastic approach.
Fold Gene Description change elF2 signaling E1F1AX Eukaryotic translation initiation factor 1A, -1.343 X-Linked EIF2B3 Eukaryotic translation initiation factor 2B, -1.361 subunit 3 gamma, 58kDa EIF3B Eukaryotic translation initiation factor 3, -1.385 subunit B EIF4G1 Eukaryotic translation initiation factor 4 -1.306 gamma, 1 MAP2K1 Mitogen-activated protein kinase inase 1 1.306 PPP1R15A Protein phosphatase 1, regulatory subunit 15A 1.784 RPL7L1 Ribosomal protein L7-like 1 -1.283 RPL14 Ribosomal protein L14 -1.297 RPL36 Ribosomal protein L36 -1.424 RPL36A Ribosomal protein L36a -1.400 RPS2 Ribosomal protein S2 -1.376 RPS7 Ribosomal protein S7 -1.619 RPS15 Ribosomal protein S15 -1.641 Table 4 Molecular docking of CPT to P13K (PDB ID: 1E8Y) and eIF4A (PDB ID:2G9N).
Zhu, "Sequence variation in the Toxoplasma gondii eIF4A gene among strains from different hosts and geographical locations," Genetics and Molecular Research, vol.
It also controls initiation of translation by phosphorylating PDCD4, a tumor suppressor that is a negative regulator of eIF4A , and targets it for degradation by the ubiquitin ligase, [beta]TRCP .
The eIF4 complex is composed of three polypeptides: eIF4E (the cap binding protein), eIF4A (an RNA helicase), and eIF4G (scaffolding protein).
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