EIF4E

AcronymDefinition
EIF4EEukaryotic Translation Tnitiation Factor 4E
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Among eIF4E family members, eIF4E1 plays the central role in mRNA recruitment.
REOVIRUS INFECTION CHANGES TRANSCRIPT LEVELS OF EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (eIF4E) FAMILY MEMBERS AND eIF4E-BINDING PROTEIN (4E-BP) IN THE BLUE CRAB CALLINECTES SAPIDUS
Regulation of cap-dependent translation by eIF4E inhibitory proteins.
Evaluation of mTOR signaling pathway proteins in rat gastric mucosa exposed to sulfite and ghrelin
In addition, several proteins involved in translational machinery, like EIF1, EIF3J, and EIF4E, and different 40S ribosomal proteins are among the underexpressed group of proteins.
Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy
Activated MEK-ERK signaling enhances eukaryotic translation initiation factor 4E (eIF4E) phosphorylation via activated MAPK-interacting protein kinase-1 (MNK1), which may lead to enhancement of P2X4R translation.
Purinergic signaling in microglia in the pathogenesis of neuropathic pain
This is associated with a redistribution of eIF4E from an active complex (i.e., eIF4E-eIF4G) to an inactive complex (i.e., eIF4E-4EBP1), thereby preventing mRNA translation.
Alcoholic myopathy: Pathophysiologic mechanisms and clinical implications
4EBP1 binds to the translation initiator factor eIF4E, repressing protein synthesis.
The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications
Initiation begins with the assembly of eIF4F complex comprising eIF4E, eIF4G, and eIF4A onto the 5' [m.sup.7]G cap (Figure 1).
Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression
For instance, SGs induced by glucose deprivation contain eukaryotic initiation factor eIF4E and eIF4G proteins, mRNAs, and the poly(A)-binding protein Pab1 [12,13], whereas SGs induced by oxidative stress have distinct major components such as eIF2 and downstream factors [6].
Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases
Consistently, NnV suppressed phosphorylation of S6 and eIF4E. Despite the inactivation of PI3K-mediated p-Akt (Thr308), mTOR1 inhibition still promotes feedback activation of mTOR2-driven phosphorylation of Akt at Ser473 [32, 33].
Anticancer Effect of Nemopilema nomurai Jellyfish Venom on HepG2 Cells and a Tumor Xenograft Animal Model
MiR-1 protects heart structure and functions against cardiac hypertrophic responses by directly targeting and inhibiting translation of many signaling molecules including eukaryotic initiation factor 4E (Eif4e), Mef2a, Gata4, and histone deacetylase 6 (HDAC6) [7-9].
MicroRNA as a Therapeutic Target in Cardiac Remodeling
eIF4E association with 4E-BP decreases rapidly following fertilization in sea urchin.
Complexity of yolk proteins and their dynamics in the sea star Patiria miniata
(44) EIF4E is the cap-dependent translation initiation factor to shut off host protein synthesis.
The role of microRNAs in enteroviral infections
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