We found no sensitive immunohistochemical marker of myoepithelial differentiation for the CCCs studied, thus favoring a histomorphogenesis distinct from that of EMECs and CCMECs.
The differential diagnosis of clear cell salivary neoplasias encompasses a broad range of possibilities, including primary salivary clear cell tumors, such as clear cell carcinoma (CCC), epithelial-myoepithelial carcinoma (EMEC), and clear cell myoepithelioma/myoepithelial carcinoma (CCMEC), as well as clear cell variants of other salivary tumors, including acinic cell carcinoma, oncocytoma, and mucoepidermoid carcinoma.
In this article, we review our clinicopathologic experience with this group of rare tumors, which includes CCC, EMEC, and CCMEC, and investigate evidence of myoepithelial differentiation using monoclonal antibody to calponin, a novel and sensitive marker of smooth muscle phenotype.
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