All MPD and EMPD samples were routine stained by HE and were evaluated separately by two independent pathologists (Songxia Zhou and Guohong Zhang).
Finally, 88 MPD and 72 EMPD could be used for simultaneous analysis of ER and AR.
The typical Mohs technique for EMPD
is to delineate a tumor-free area peripherally, and then excise the central tumor and tumor-bearing islands.
CD8, Granulysin, TIA-1, and Perforin in Invasive and NonInvasive EMPD. First, to compare the profiles of tumor-infiltrating cytotoxic T lymphocytes between invasive and noninvasive EMPD, we employed immunohistochemical staining for CD8 (Figures 1(a) and 1(b)), granulysin (Figures 1(c) and 1(d)), TIA-1 (Figures 1(e) and 1(f)), and perforin (Figures 1(g) and 1(h)).
CD163, B7H1, MMP-9, and ARG1 in Invasive EMPD. To further investigate the profiles of immunosuppressive cells around the tumors in invasive and noninvasive EMPD, we performed immunohistochemical staining of CD163 (Figures 3(a) and 3(b)) as well as the functional markers for M2 macrophages, MMP-9 (Figures 3(c) and 3(d)), B7H1 (Figures 3(e) and 3(f)), and ARG1 (Figures 3(g) and 3(h)).
EMPD often presents as a well-defined, moist, erythematous, scaly, eczematous patch with hypo- or hyperpigmentation.
There are usually three patterns of EMPD: a) an in situ epithelial form without associated carcinoma, b) an epithelial form with associated adnexal carcinoma and c) associated with visceral malignancy of either genitourinary tract or gastrointestinal tract.6 EMPD cells themselves have the potential to invade the dermis and metastasize.
Not infrequently, vulvar syringoma was seemingly an incidental finding (41%; 12 of 29 cases) and was a secondary diagnosis in 4 cases of melanocytic nevi (3 atypical, 1 congenital) (Figure 5), 4 cases of lichen sclerosus (Figure 6), 3 cases of lichen simplex chronicus, as well as single cases of squamous cell carcinoma, EMPD, condyloma, seborrheic keratosis, lymphangioma, and epidermoid cyst.
Primary EMPD can be either an intraepithelial neoplasm with or without an associated invasive component or a manifestation of an underlying primary adenocarcinoma.
Moisture Properties Coefficients Interior EMPD
A B C D Construction Value Gypsum wall 0.004 0.072549 0.397173 0.007774 11.7057 board 1/16 in.
The EMPD model is a simplified lumped approach to simulate surface moisture adsorption and desorption (Kerestecioglu et al.
In the EMPD approach, Equation (7) and (8) are solved by assuming that only a thin layer near the interior surface interacts with the indoor air (the so-called sorption-active layer or humidity buffer), see Figure 4.