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In patients with adenocarcinoma without a mucinous component, the mean EpCAM expression equalled 32.2%, while patients with adenocarcinoma with a mucinous component had the lower EpCAM expression (15.8%) The higher expression of this protein was found in the intestinal type of cancer (33.4%) according to the Lauren classification (p=0.037).
 Nonstandard abbreviations: EV, extracellular vesicle; AM, acetoxymethyl; CFSE, carboxyfluorescein succinimidyl ester; di-8-ANEPPS, 4-(2-[6-(dioctylamino)-2-naphthalenyl]ethenyl)-1 (3-sulfopropyl)pyridinium; PKH67, Paul Karl Horan 67; EpCAM, epithelial cell adhesion molecule; CD61, integrin, [beta]3; FITC, fluorescein isothiocyanate; APC, allophycocyanin; SEC, sizeexclusion chromatography; mAb, monoclonal antibody; PE, phycoerythrin; MESF, molecules of equivalent soluble fluorochrome; PPV, positive predictive value.
Syndrome Gene Percentage/ Cancer risks 95% CI syndrome Lynch MLH1 60% Colorectum 52 (31-90) syndrome Endometrium 21 (9-82) Stomach 11-19 Ovary 38 (3-81) Hepatobiliary 2-7 Upper urinary tract 4-5 Pancreas 3-4 Small bowel 1-4 Glioblastoma 1-3 Lynch MSH2 20% Colorectum 49 (29-85) syndrome Lynch MSH6 6% Colorectum 18 (13-30) syndrome Endometrium 17 (8-47) Stomach <3 Ovary 1 (0-1) Urinary tract <1 Lynch PMS2 12% Colorectum 15-20 syndrome Endometrium 15 Lynch EPCAM <3% Endometrium 57 (22-82) syndrome Stomach 11-19 Ovary 20 (1-66) Hepatobiliary 2-7 Upper urinary tract 4-5 Pancreas 3-4 Glioblastoma 1-3 Table 2: Germline and somatic genetic and epigenetic characteristics of HNPCC-associated cancer syndrome.
BerEP4 is a monoclonal antibody which can detect the presence of EpCAM antigen found on BCC cells.
The expression of AFP and EpCAM was evaluated and considered to be binary, considering a positive marking when more than 10% of the tumor cells expressed the markers in a moderate or strong form.
The rs13388259 SNP is an intergenic polymorphism located on the short arm of Chromosome 2 (Ch2:47,343,700) between the BCYRN1 and EPCAM genes.
Attard, "Epithelial EPCAM expression does not correlate with intestinal absorptive function in the milder phenotype of tufting enteropathy," Gut, vol.
Udey, "EpCAM expressed by murine epidermal Langerhans cells modulates immunization to an epicutaneously applied protein antigen," The Journal of Investigative Dermatology, vol.
Genes Tested AtP ALK APC ATM BAP1 BRCA2 BRIP1 BUB1B CDC73 CDH1 CEP57 CHEK2 CYLD DDB2 DICER1 ERCC3 ERCC4 ERCC5 EXT1 EXT2 FANCD2 FANCE FANCF FANCG FANCI GATA2 GPC3 HNF1A HOXB13 HRAS MLH1 MHS2 MSH6 MUTYH NBN PHOX2B PMS1 PMS2 PPM1D PRF1 RAD51D RBI RECQL4 RET RHBDF2 SDHC SDHD SLX4 SMAD4 SMARCA4 TP53 TSC1 TSC2 VHL WT1 BARD1 BLM BMPR1A BRCA1 CDK4 CDKN1C CDKN2A CEBPA DI53L2 EGFR EPCAM ERCC2 EZH2 FANCA FANCB FANCC FANCL FANCM FH FLCN KIT MAX MEN1 MET NF1 NF2 NSD1 PALB2 PRKAR1A PTCH1 PTEN RAD51C RUN XI SBDS SDHAF2 SDHB SMARCB1 STK11 5UFU TMEM127 WRN XPA XPC This chart shows all 98 cancer susceptible genes included in this new test.
Yang, "By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis," Oncotarget, vol.
It was recently shown that epithelial cell adhesion molecule (EpCAM) was upregulated via active DNA demethylation catalysed by EZH2 and Tet2 in conjunction with nuclear factor kappa B (NF-K[beta]) and RelA .
By targeting EpCAM with the aptamer as well as with a siRNA of EpCAM, the systemically delivered chimera resulted in the regression of tumor xenografts derived from MCF-7.
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