2] Nonstandard abbreviations: CTC, circulating tumor cell; EpCAM, epithelial cell adhesion molecule; CK, cytokeratins; DAPI, 4',6-diamidino-2-phenylindole; HER2, human epidermal growth factor receptor 2; FACS, fluorescence-activated cell sorting; ERCC1
, excision repair cross-complementation group 1; MUC1, mucin 1, cell surface associated; CA, cancer antigen.
expression by immunohistochemistry and EGFR mutations in resected non-small cell lung cancer.
Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1
on the risk of basal cell carcinoma among Caucasians after age 50.
Following our previous observation that circulating tumor cells (CTC) in the blood of ovarian cancer patients are predictive for a poor overall survival (OS) (21), and given our hypothesis that the negative prognostic impact of CTC may arise from a cellular phenotype, being associated with platinum resistance, we asked whether CTC expressing the excision repair cross-complementation group 1 (ERCC1
)  gene in the form of the ERCC1
transcript may be superior to commonly studied primary tumor-based ERCC1
protein detection in predicting response to platinum-based chemotherapy.
A team of researchers in Italy measured ERCC1
mRNA levels in lung cancer patients receiving cisplatin.
High gene expression of TS1, GSTP1, and ERCC1
are risk factors for survival in patients treated with trimodality therapy for esophageal cancer.
In our preliminary study of human lymphocytes from individuals exposed to drinking water As, As exposure was correlated in a strongly dose-dependent manner to decreased expression of three nucleotide excision repair genes: ERCC1
, XPB, and XPF (Andrew et al.
The results conclude that low expression of BRCA1 mRNA is associated with better Progression Free Survival (PFS) and statistically significant longer survival of sarcoma patients after treatment with Yondelis and that high mRNA expression levels of XPD or ERCC1
genes do not have a negative impact on the clinical outcome of those patients.
Clinical trials: I-SPY 2, BATTLE, BATTLE-2, DERMA, BRIM2, BRIM3, ERCC1
, MARVEL, PRECEDENT, PROFILE 1005.
Our findings revealed high expression of BRCP (91%) and MRP1 (100%), and low expression of ERCC1
(11%), which suggest why these tumors have a high level of drug resistance," said Michael M.
EGFR, KRAS, BRAF, PIK3CA and EML4-ALK tests have received both CE declarations for marketing in Europe and SFDA approval for clinical use in China, ROS1 and ERCC1
assays are CE marked for IVD use in Europe.
70) Cell cycle regulators, such as p53, Ras-Raf-Mek, and ERCC1
, are other commonly investigated prognostic markers in lung cancer.