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ERCC2Excision Repair Cross-Complementing 2 (gene)
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In addition to Witwer, ERCC2 participants include Michael Paulaitis and Zhaohao Liao of Johns Hopkins; Wyatt Vreeland of the National Institute of Standards and Technology; Angela Zivkovic and Carlito Lebrilla of the University of California, Davis; Juan Tosar and Alfonso Cayota of the Institut Pasteur de Montevideo; George Daaboul of NanoView Diagnostics; and Andrey Turchinovich of SciBerg.
Statistically significant association of the single nucleotide polymorphism (SNP) rs13181 (ERCC2) with predisposition to squamous cell carcinomas of the head and neck (SCCHN) and breast cancer in the North Indian population.
ERCC2, encoded by a gene located at chromosome 19q13.3, is an ATP-dependent helicase that mediates DNA unwinding for the initiation of nucleotide excision repair (NER) [8].
Mittal, "Impact of nucleotide excision repair ERCC2 and base excision repair APEX1 genes polymorphism and its association with recurrence after adjuvant BCG immunotherapy in bladder cancer patients of North India," Medical Oncology, vol.
In our patient, full sequencing of the coding regions of the genes XP-A, XP-B/ERCC3, XPC, XP-D/ ERCC2, XPE/DDB2, XPF/ERCC4, XP-G/ERCC5, and XP variant/POLH and confirmation of variants by Sanger sequencing were performed, revealing a germline mutation in the XPC gene predicted to result in premature protein termination (p.Lys183*).
Large TP53-regulated gene cluster with many hub proteins related to tumor suppression (TP53, STK11, CDKN1a, CDKN2A, TSC2) and excision DNA repair (PARP1, SP1, PML and ERCC2) indicates that SHS-survived eMSC trigger stress protection.
Objective: Several previous studies have reported the role variant of ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms in the risk of glioma but the results of these studies are inconsistent.
Some genes that influence DNA repair are XRCC1, [XRCC.sub.2], [XRCC.sub.3], XPC, XPD/ ERCC2, XPFand RAD51 [7].
Respecto al papel que desempena la expresion de los genes asociados a la reparacion de las rupturas en el ADN (ERCC1, ERCC2, XRCC1) en respuesta al tratamiento quimioterapeutico con cisplatino, un estudio mostro evidencia de la asociacion entre un bajo nivel de expresion del gen ERCC1 con un elevado nivel de respuesta (RR) en pacientes con CG avanzado que recibieron S-1 y cisplatino (43).
Exceptions to this trend are the Xeroderma pigmentosum complementation group D protein, XPD (also known as ERCC2 or Rad3), and Xeroderma pigmentosum complementation group B protein, XPB [135], which both form part of TFIIH in eukaryotes and are encoded by many archaea.
XRCC1 codon 399 and ERCC2 codon 751 polymorphism, smoking, and drinking and risk of esophageal squamous cell carcinoma in a North Indian population.