ERCC4Excision Repair Cross Complementing 4 (gene)
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By adopting this strategy they have succeeded in identifying pathogenic mutations responsible for this disease in the ERCC4 gene, which had already been linked to two other rare diseases: xeroderma pigmentosum and a type of progeria.
The ERCC4 gene can therefore be responsible for three different diseases.
No relationship was found between the expression of ERCC4 and response to chemotherapy in oesophageal adenocarcinoma [33] or GC [54].