ERDJ4Microvascular Endothelial Differentiation Gene 1
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Furthermore, the mRNA expression levels of ER stress responsive genes (Grp78, chop, Xbp-1s, Atf4, and Erdj4) were significantly lower in HFD-fed obese mice treated with DNJ than in control mice treated with the vehicle (Figure 4(b)).
XBP1s activates transcription of major genes encoding ERAD components, such as ERdj4 [89], HRD1 [90], EDEM (ER degradation enhancing a-mannosidase like protein) and EDEM2 [91].
Snapp, "ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery," The Journal of Biological Chemistry, vol.