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ERKExtracellular Signal-Regulated Kinase
ERKExtracellular Receptor Kinase
ERKEverett Raymond Kinstler (painter)
ERKElectronic Records Keeping
ERKExchange Roller Kit (Canon desktop scanner part)
ERKExternally Regulated Kinases
References in periodicals archive ?
The identified 11 proteins were further analyzed based on their interactions with EGFR, Ras, Raf, MEK and ERK.
First author Dr Jonathan Goke from Stem Cell and Developmental Biology at the GIS said, "The ERK signaling pathway has been known for many years, but this is the first time we are able to see the full spectrum of the response in the genome of stem cells.
By elucidating the role of ERKs in B cell differentiation, the current research provides valuable insight into a little-understood area of immune response, promising advances in drug discovery and offering hope to autoimmune disease and allergy sufferers around the world.
As single agents, ganetespib effectively blocked both ERK and AKT/mTOR signaling; by contrast, PI3K/mTOR inhibitors blocked their targets while activating ERK.
1) on BDNF/TrkB/ERK and BDNF/TrkB/PI3K signaling pathways by using TrkB, ERK and PI3K antagonists to specifically antagonize various signaling pathways, and Western blot assay was used to evaluate the changes of neurotrophic factor BDNF and key proteins expression in various pathways before and after antagonizing to further reveal its molecular mechanism in neuro-protective effect.
Tibia sections were blocked with 5% goat serum for 1 hr to prevent nonspecific binding, incubated overnight with the antibody for either Runx2 or phosphorylated ERK (1:200), and then treated with anti-rabbit or anti-mouse FITC (fluorescein isothiocyanate)-labeled secondary antibody (1:500; Sigma-Aldrich) for 1 hr.
Both ERK and MDM2 are wellknown oncoproteins, but their collaboration was previously unknown," Hung reveals.
The findings suggest that lenalidomide acts in part by interrupting Akt and ERK signaling, but has no effect on Bcl-2 or Bcl-xl.
The targets included c-src which can activate focal adhesion kinase (FAK), PYK2, a soluble form of FAK, and the MAP kinases ERK 1/2, p38 and SAPK/JNK, which can upregulate cytokines that upregulate MMPs.
The studies reported here utilized non-optical, AMMP (acoustic membrane microparticle) technology to quantitate the activity state of multiple kinases including EGFR, MEK, ERK, AKT, p38 and JNK in their native state and included the detection of the MEK-ERK heterodimer highlighting the ability of the technology to detect weak and transient low affinity interactions.
The use of ERK activation inhibitor (PD98059) abrogated the [delta]T3-mediated downregulation expression melanogenesis-related proteins and restored melanin production.