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ESAT-66-Kilodilation Early Secreted Antigenic Target
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Additive effect of recombinant Mycobacterium tuberculosis ESAT-6 protein and ESAT-6/CFP-10 fusion protein in adhesion of macrophages through fibronectin receptors.
Further analysis of the results indicated a serological heterogeneity against various antigens (PGL-I, 45 kDa, ESAT-6 and CFP-10).
ESAT-6 and CFP-10, being secreted proteins, may be produced in the early active phase of infection that in turn may give rise to early antibody responses.
Performance of recombinant ESAT-6 antigen (ML0049) for detection of leprosy patients.
Identification and characterization of ESAT-6 homologue of Mycobacterium leprae and T-cell cross reactivity with Mycobacterium tuberculosis.
Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6.
After incubating the differentiated THP-1 cells with ESAT-6 (2.
Differentiation was verified by observing morphological changes in the cells before treating them with the recombinant proteins, namely ESAT-6 (2.
Downregulation by recombinant ESAT-6/ CFP-10 in its optimum concentration (60%) was greater than that observed for ESAT-6 (50%) or CFP-10 (40%) alone.
As is shown in figure 3, the ESAT-6 protein (10 [micro]g/mL) inhibited LPS-induced ROS production in the THP-1 cells by 60%, CFP-10 protein (5 [micro]g/mL) by 50%, and ESAT-6/CFP-10 protein (1.
25 [micro]g/mL were optimal for the recombinant ESAT-6, CFP-10, and ESAT-6/ CFP-10 proteins, respectively.
The ESAT-6, CFP-10, and ESAT-6/ CFP-10 proteins at their optimum concentrations inhibited LPS-induced NO production in the THP-1 cells by 50-60%.