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ESAT-66-Kilodilation Early Secreted Antigenic Target
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In addition, the Nano-Disk MS assay vastly outperformed both AFB smear microscopy and culture, detecting ESAT-6 or CFP-10 peptide in 85.3% of culture-negative and 87.2% of smear-negative cases.
Avidities of IgG against PPD, ESAT-6, CFP10-ESAT-6, and Ag85b were analyzed as previously reported with modifications [17, 18].
It has been found that CFP-10 and ESAT-6 antigens distinguish individuals with active TBI from healthy individuals with high diagnostic sensitivity and specificity, whereas they are inadequate for the discrimination of active TBI from LTBI.
In the present study, QDs were immobilized with a specific oligonucleotide (P1) and AuNPs was conjunct with another specific oligonucleotide (P2) against ESAT-6 region to develop a specific and sensitive sandwich-form FRET-based biosensor to detect and differentiate M.
(2004) used polymerase chain reaction (PCR) to amplify 14 kDa, 37 kDa and esat-6 antigenic genes from genomic DNA.
(5) At our laboratory we have investigated, in the recent past, the serodiagnostic potential of serine-rich 45 kDa protein (45kDa;ML0411),early secreted antigenic target-6 (ESAT-6; ML0049), culture filtrate protein-10(CFP-10; ML0050) and phenolic glycolipid-I(PGL-I) antigens.
Cellular immune responses to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium avium complex and those with pulmonary disease due to Mycobacterium tuberculosis.
Cells (250,000/well) were added to duplicate wells containing antigen (ESAT-6 or CFP-10) or mitogen.
Standard recombinant CFP-10 and ESAT-6 were trypsin-digested and analyzed on an AXIMA Resonance MALDI-TOF MS to select monovalently charged target peptide ions.
The ESAT-6, CFP-10, and ESAT-6/CFP-10 recombinant proteins used in this study were cloned in our laboratory.
QuantiFERON-TB Gold (QFT-G) is an IGRA that utilizes two Mtb-specific antigens, ESAT-6 and CFP-10.
Briefly, 1 mL of blood was drawn into vacutainer (Becton Dickinson) tubes coated with either saline (negative control tube) or ESAT-6, CFP-10, and TB 7.7 peptides (M.