Butzner, "Evaluation of the ESPGHAN
celiac guidelines in a North American pediatric population," American Journal of Gastroenterology, vol.
According to the newly published ESPGHAN
guidelines, omission of duodenal biopsy may be considered for pediatric patients with anti-tTG IgA antibodies >10x the upper limit of normal (ULN) for curve-based assays together with gluten-dependent symptoms and the presence of HLA DQ2 and/or DQ8.
Our study identified CD in patients with T1DM by using the diagnostic criteria recommended by the ESPGHAN
. This included the combination of two highly sensitive and specific tests (anti-tTGA and EMA), and by performing 6 to 8 duodenal biopsies (including the bulb) in patients with positive serology.
With the publication of the new ESPGHAN
guidelines, HLA analysis has gained a new significance in the diagnosis of CD.