P-V loop derived load-dependent and -independent contractility parameters (EF and slope of ESPVR) were significantly lower in STZ-induced diabetic animals compared to nondiabetic controls, suggesting impaired systolic performance in type-1 DM.
A marked impairment of LV contractility and systolic dysfunction (decreased EF and slope of ESPVR) could be demonstrated only in type-1 DM, which was accompanied by severe nitrooxidative stress, cardiomyocyte apoptosis, and myocardial fibrosis.