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22 patients (22%) had advanced retinopathy in any eye including proliferative diabetic retinopathy (PDR) and advanced diabetic eye disease according to ETDRS classification of diabetic retinopathy, and 46 (46%) had mild to moderate non-proliferative diabetic retinopathy (NPDR) (table-I).
An improvement of + 23 letters is equivalent to reading an additional four lines of letters on the ETDRS eye chart, the standardized eye chart used to measure visual acuity in clinical trials.
This recovery at week 72 could not yet completely offset deterioration from baseline through the acute phase: GS010-treated eyes were still below baseline by 0.192 LogMAR (-10 ETDRS letters equivalent), compared to 0.380 LogMAR (-19 ETDRS letters equivalent) at Week 48.
Participants underwent monthly ophthalmic examination for: (a) intraocular pressure (IOP) monitoring via Goldmann Applanation Tonometry, (b) adverse event monitoring, (c) standardised BCVA assessment in ETDRS letters and (d) colour fundus photography.
Using the telescope type and telescopic glasses through which patients could see the best, distant BCVA values of both the eyes were determined with the help of the ETDRS scale and recorded.
Diabetic retinopathy was classified according to Early Treatment Diabetic Retinopathy Study (ETDRS) classification as mild, moderate, severe and very severe non-proliferative diabetic retinopathy and proliferative diabetic retinopathy.
The VA values measured on a decimal scale were converted to logMAR and Early Treatment Diabetic Retinopathy Study (ETDRS) as corresponding letters.
In the present study, DR is thus classified as (i) no-DR = no diabetic retinopathy, (ii) any-DR = level 20 to 35 of the ETDRS, and (iii) STDR = level 43 or worse as defined by the ETDRS.
The Early Treatment Diabetic Retinopathy Study (ETDRS) showed that focal/grid PC reduced the risks of losing >3 lines of vision by approximately 50% for 3 years after treatment .
Best-corrected VA was measured at a 4-meter distance using a retro-illuminated Early Treatment Diabetic Retinopathy Study (ETDRS) chart by an ophthalmic technician who was trained in the ETDRS protocol.
VectorVision specialises in the standardisation of contrast sensitivity, glare sensitivity, low contrast acuity, and ETDRS acuity vision testing.
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