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Cryptic 3q26 aberrations partly explain abnormal expression of EVI1 in AML cases without cytogenetically recognizable translocations in this locus.
Clinical and prognostic significance of EVI1 epression in acute myeloid leukemia [dissertation].
High levels of expression of several genes including EVI1, BAALC, MN1, and ERG have been found to be prognostically relevant in AML [8, 9].
AMLprofiler is designed to detect low expression levels of BAALC and high expression levels of EVI1 genes.
EVI1: CHROMOSOMAL LOCALIZATION, GENOMIC STRUCTURE, AND NORMAL FUNCTION
The most important gene relevant to this review at the chromosome 3q26.2 locus is EVI1. (22-24) EVI1 (Figure 2, A), a proto-oncogene, is a nuclear transcription factor containing 2 domains of zinc finger (ZF) repeats of 7 and 3 at its N- and C-termini, respectively.
Whether Evi1 overexpression plays class II-like roles is also not clear.
(2013) The shortest isoform of C/ EBPbeta, liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model.
Arsenic trioxide and thalidomide combination produces multi-lineage hematological responses in myelodysplastic syndromes patients, particularly in those with high pre-therapy EVI1 expression.
Interestingly, CDH2/4/6/17-enriched genes including two SC-TFs (MCM2 and FOXM1) were mainly grouped into a cluster that can be regulated by Nuclear Transcription Factor Y (NFY) and/or MECOM (EVI1) (Table 3), both of which have been reported to be involved in stem cell regulation [41, 42].
(10) Acute myeloid leukemias with more uncommon rearrangements of t(6; 9) with DEK-NUP214 fusion, inv(3) or t(3; 3) with RPN1MECOM (EVI1) fusion, and t(1; 22) with RBM15-MKL1 fusion are also considered to be discrete WHO subtypes.
Several of them are oncogenes, such as the BCL2, MYB, EVI1, TCL1B, and RUNX1 genes.
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- Evgraf Fedorovich Krendovskii
- Evgraf Kovalevskii
- Evgraf Krendovskii
- Evgraf Petrovich Chemesov
- Evgraf Petrovich Kovalevskii
- Evgraf Stepanovich Fedorov
- Evgraf Tiurin
- Evgrafov, Aleksei
- Evgrafov, Aleksei Romanovich
- Evgrafov, Georgii
- Evgrafov, Georgii Konstantinovich
- Evian Accords
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