The results revealed that overexpression of HPSE promoted the proliferation of EVTs and downregulation of HPSE suppressed trophoblasts growth.
In conclusion, our study is the first to reveal a strong association between HPSE and the behavior of EVTs. HPSE plays an important role in regulating the biological behavior of EVTs.
However, the function of HPSE in mediating the biological behavior of EVT in vitro and the underlying mechanisms remain unexplored.
In the present study, we demonstrated that HPSE had a considerable role in the biological behavior of EVT. Overexpression of HPSE promoted EVT growth and invasion.
The human first-trimester EVT cell line HTR8/SVneo cells were cultured in RPMI 1640 growth medium (HyClone, USA) supplemented with 10% fetal bovine serum at 37[degrees]C with 5% C[O.sub.2].
Thus, the mechanism by which HPSE controls the EVT invasion was thought to be relevant to the activation of the MAPK pathway.
Myers and Thyer continually speak in their article of EVTs as being "effective," a usage that blurs the distinction between efficacy and effectiveness.
Does the profession of social work want to legislate that our clients must have access to EVTs when the relationship of EVTs to clinical practice is at best problematic?
At a debate on EVTs at the APA midwinter convention in March 1997, Professor Bert Karon of Michigan State University stated, "I don't believe that we can have a fiat from above.
Fensterheim and Raw (1996b) argue that psychiatric diagnosis, a backbone of EVT research, and especially the DSM system of diagnosis (American Psychiatric Association, 1994), has a different purpose in research and clinical practice.