EZH1Enhancer of zeste homolog 1
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PHF1 encodes the PHD finger protein 1 (PHF1), which is involved in chromatin structure regulation, forming polycomb repressive complex 2 (PRC2) with EZH1, EZH2, SUZ12, regulating histone H3 lysine 27 (H3K27) methylation.
Although the reason for this discrepancy are not yet clarified, an EZH2 homologue EZH1 may compensate for some functions of EZH2 in the absence of EZH2, but may not function in the absence of ASXL1.