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References in periodicals archive ?
Nischal, "Incidence of early-onset glaucoma after infant cataract extraction with and without intraocular lens implantation," The British Journal of Ophthalmology, vol.
Among the patients, 18.1% (76/420) had early-onset glaucoma (under 4-year-old group).
The etiology of early-onset glaucoma is known to involve anterior chamber angle anomalies.[18],[19] Juvenile- or adulthood-onset glaucoma has been attributed to elevated episcleral venous pressure.[20] Our results strongly support this theory.
The anterior chamber angle and outflow defects in early-onset glaucoma are similar to those in primary congenital glaucoma (PCG), which represents another eye anterior anatomical defect and the most common form of glaucoma in infants.[22] Tanwar et al .[23] have found mutations in a PCG-related gene, CYP1B1, in SWS patients with early-onset glaucoma.
BIOCHEMISTS IN the US have identified compounds which could potentially be used to tackle early-onset glaucoma, by targeting protein 'clumps' which form in the eye.
To do that, the researchers must find more family members or identify other people suffering from the same type of early-onset glaucoma. The group has already initiated such an effort, and Stone says he's confident they'll have the precise location of the gene within a few years.
Buys et al., "Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene," American Journal of Human Genetics, vol.
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