Characterization of endothelium-derived hyperpolarizing factor
as a cytochrome P450-derived arachidonic acid metabolite in mammals.
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Gutierrez et al., "Crucial role of NO and endothelium-derived hyperpolarizing factor
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Vascular endothelium regulates the underlying smooth muscle layer and vascular tone by release of endothelium-derived relaxing factors such as nitric oxide (NO), prostaglandins, and endothelium-derived hyperpolarizing factor
(EDHF) as well as vasoconstricting factors such as endothelin, superoxide (O2-), and thromboxane (25, 28-32).