Plant lignans in whole grain cereals, seeds, fruits, and vegetables are converted to enterolactone
by bacterial flora in the colon.
Phloem powder was shown to increase serum enterolactone
Excretion of the lignans enterolactone
and enterodiol and of equol in omnivorous and vegetarian women and in women with breast cancer.
These anticancer effects of (-)-sesamin in vivo are remarkable, since sesamin is metabolized in animals and men to enterolactones
(Liu et al.
Milk concentration of the mammalian lignan enterolactone
, milk production, milk fatty acid profile, and digestibility in dairy cows fed diets containing whole flaxseed or flaxseed meal.
Compared to the study subjects with the lowest enterolactone
levels, the women with the highest blood levels of this biomarker had an approximately 40 percent lower mortality risk.
7),(8) A study of Finnish men showed significant associations between elevated levels of the lignan byproduct enterolactone
and reduced risk of death from coronary heart disease and cardiovascular disease.
However, a recently published study from Europe (Norfolk-EPIC) found no association of estimates of microbial enterolactone
production and breast cancer risk, although they did observe a significant decrease in colon cancer risk in women.
Diet-derived polyphenol metabolite enterolactone
is a tissue-specific estrogen receptor activator.
We've been focusing on two lignans, enterodiol and enterolactone
," says Wendy Demark-Wahnefried of the MD Anderson Cancer Center in Houston.
Secoisolariciresinol diglucoside (SDG), a flaxseed lignan, and its metabolites secoisolariciresinol (SECO), enterodiol (ED), and enterolactone
(EL), which are all formed in the body have antioxidant activity.
Use of oral antimicrobials decreases serum enterolactone