SDG hydrolysis is an important feature in probiotic bacteria to enhance the release of SECO, improving its bioavailability for absorption by colonic mucosa and/or the biotransformation to enterodiol and enterolactone
by intestinal microorganisms [118, 124].
Enterodiol and enterolactone
, two major diet-deriveted polyphenol metabolites have different impacto on Era transcriptional activation in human breast cancer cells.
Other non-flavonoid polyphenols * Other tannins (cereals, fruits, berries, beans, nuts, wine, cocoa) * Curcuminoids: curcumin (turmeric) * Stilbenes: cinnamic acid, resveratrol (grapes, wine, blueberries, peanuts, raspberries) * Lignans: secoisolariciresinol, enterolactone
, sesamin (grains, flaxseed, sesame seeds) Terpenoids 1.
Dietary sesamin is converted to enterolactone
Adjusting for a wide range of potential cofounders, including age, gender, race, urinary creatinine, poverty, body mass index, smoking, and smoke exposure, they found that, for every natural log increase in urinary enterolactone
, the odds of asthma decreased by 8%.
After the trial, plasma levels of enterolignans in the active group increased substantially (10 fold increase for enterolactone
and 50 fold increase for enterodiol), as did levels of the ra-3 fatty acid ALA (by 2 fold).
In humans and other animals, ingested SDG is converted by bacteria in the colon to the biologically active lignans enterodiol (END) and enterolactone
Milk concentrations of the mammalian lignans enterolactone
and enterodiol, milk production, and whole tract digestibility of dairy cows fed diets containing different concentrations of flaxseed meal.
Madden et al., "Flaxseed-derived enterolactone
is inversely associated with tumor cell proliferation in men with localized prostate cancer," Journal of Medicinal Food, vol.
Strong significant associations were observed for the so called 'mammalian phytoestrogens', enterolactone
and equol, in postmenopausal women (P < 0.05) but not in men.
In the bowel, these substances are turned into enterolactone
, which is absorbed by the mucous tissue and which was determined by the Heidelberg researchers as a biomarker in the patient's blood.
(2006), lignans can be converted by intestinal microbiota to the mammalian lignans, enterodiol and enterolactone
, which may have protective effects against hormone-related diseases such as breast cancer.