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EPHXEpoxide Hydrolase
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The report provides comprehensive information on the Soluble Epoxide Hydrolase (Epoxide Hydratase or Aryl Epoxide Hydrase or EC 3.
Soluble epoxide hydrolase (sEH), a member of the epoxide hydrolase family, is found mostly in cytosol but also in the peroxisomes of some mammalian tissues including liver, kidney, intestine and vascular tissues (Morisseau and Hammock 2013).
It aimed to determine the impact of a group of chemicals called "nitro fatty acids" on the activity of an enzyme called soluble epoxide hydrolase and the knock on effects on blood pressure.
Thus, the study concludes that the protective effect of the Mediterranean diet, combining unsaturated fats and vegetables abundant in nitrite and nitrate, comes at least in part from the nitro fatty acids generated which inhibit soluble Epoxide Hydrolase to lower blood pressure.
An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension.
Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-Stransferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.
National Food Research Institute (Tsukuba, Japan) has patented a method for isolating cDNA encoding a plant-derived epoxide hydrolase and an expression system of the enzyme in Escherichia coli are established, so as to permit the mass-scale production of the plant-derived epoxide hydrolase.
6] Phenytoin, phenobarbital, and carbemazepine are aromatic ring compounds oxidized by cytochrome p450 to arene oxides, which are then detoxified by epoxide hydrolase.
It is the balance of this activation and protective detoxification measures such as epoxide hydrolase and glutathione conjugation that determines local toxicity and carcinogenicity.
One of the strongest signs came from the gene EPHX2, which codes for epoxide hydrolase 2-an enzyme known to regulate cholesterol metabolism.