References in periodicals archive ?
Chung and her colleagues designed a synthetic protein consisting of two natural proteins fused together -- one that binds to active ErbB receptors and another that cleaves a specific amino acid sequence.
Therefore, HER-3 dimerizes with other ErbB receptors, specifically with HER-2 to become activated (l0).
ErbB and Nrg: potential molecular targets for vestibular schwannoma pharmacotherapy.
Canertinib is an irreversible inhibitor that binds covalently to specific cysteine residues in the ATP-binding pocket such as cysteine 773 of EGFR, cysteine 784 of ErbB2, and cysteine 778 of ErbB4 thereby blocking the ATP-binding site in the kinase domain of ErbB proteins, preventing their kinase activity and downstream signaling, and additionally, it also prevents transmodulation of ErbB2 [7].
Yang et al., "Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer," Molecular Cell, vol.
ErbB proteins are used now as molecular markers in therapy, since they can be targeted with either tyrosine kinase inhibitors or with specific monoclonal antibodies, for example, cetuximab and panitumumab against ErbB1 or trastuzumab and pertuzumab against ErbB2 [7, 8].
Yarden and Sliwkowski [48] determine that when EGF and its relatives bind the ErbB family of receptors, they trigger a network of signaling pathways, culminating in responses ranging from cell division to death and from motility to adhesion.
It's not just what ERBB needed, it's what I believe any successful company in our sector needs.
8,895,300); and Pancreatic endoderm cell cultures with an ERBB receptor tyrosine kinase activating agent (No.
Afatinib is a potent irreversible inhibitor of all members of the ERBB family of receptor tyrosine kinases.