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E+PEstrogen and Progestin
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Estrogen and progestin, lipoprotein(a), and the risk of recurrent coronary heart disease events after menopause.
Some are based on a 28-day regimen (21 days of active tablets that contain the same amount of estrogen and progestin followed by seven days of placebo tablets or no tablets at all), called monophasic birth control pills.
Using the most recent scientific evidence available, including long-term follow-up data from the Women's Health Initiative (WHI) studies of hormone therapy use in postmenopausal women, the task force reached the same conclusions as it had in 2005, advising against combined estrogen and progestin for prevention of chronic conditions, and also against the use of estrogen alone for the prevention of chronic conditions in postmenopausal women who have had a hysterectomy.
This disparate increase in mortality over incidence in several tumor types suggests that the estrogen and progestin [combination] is doing something to the behavior of existing tumors," commented Dr.
In addition, breast cancer risk was slightly increased in the combination estrogen and progestin group, but not for the estrogen-only group.
He notes that the combination therapy delivers estrogen and progestin in regular doses every day.
Results from two recent studies in the New England Journal of Medicine and one in the Lancet have mounted yet more evidence suggesting that combination estrogen and progestin is bad for a post-menopausal woman's heart and breasts.
Combined estrogen and progestin hormone therapy has reached new levels of controversy in recent months.
Last July, the Women's Health Initiative (WHI) hormone study was stopped because the researchers found that estrogen and progestin increased the risk for breast cancer.
Most recently, in July 2002, federal officials announced they had halted a WHI trial on hormone therapy because it showed that women raking a combination of estrogen and progestin hormones, marketed as Prempro, have an increased risk for breast cancer, heart disease, and stroke.
(23) The results of a recent large study of hormone-replacement therapy (HRT) in menopause found that the combination of estrogen and progestin, rather than estrogen alone, increased risk of breast cancer.
Now the US Food and Drug Administration has ordered that all drugs containing estrogen or estrogen and progestin for use by menopausal women must include a warning on the drug label highlighting the possible increased risks for breast cancer, heart attacks, stroke and blood clots for women taking the medication.