Shaodong, et al., Comparision of Ultraviolet Detection, Evaporative Light Scattering Detection
and Charged Aerosol Detection Methods for LC Determination of Anti-Diabetic Drugs, J.
Examples include analysis involving trace levels of analytes using UV-Vis, fluorescence and evaporative light scattering detection
, specialized environmental analysis such as Environmental Protection Agency (EPA) Method 8315A for the determination of aldehydes and ketones, or EPA Methods 550, 610 and 8310 for the determination of polycyclic aromatic hydrocarbon (PAH) compounds in drinking water.
The system departs from current flash chromatography technology by combining traditional ultraviolet (UV) detection with evaporative light scattering detection
to detect compounds that would have been missed by UV alone.
It is an improved detection technique of evaporative light scattering detection
. CNLSD is a universal detection method since light scattering is not compound selective and has detection limits comparable to those of fluorescence detection [19, 20].
To overcome these issues, other instrumental techniques used included pulsed electrochemical detection on gold electrode [16, 17], mass spectrometric detection , evaporative light scattering detection
, post-column ligand displacement reaction with fluorescence detection  and chemiluminescence detection .
Compared to evaporative light scattering detection
(ELSD), where light scattered from dry particles is measured, CNLSD is over 100 times more sensitive .