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References in periodicals archive ?
The electrophysiological data obtained by recording in CA3 pyramidal neurons show some substantial differences in a number of features on both spontaneous excitatory postsynaptic currents (sEPSCs) and evoked excitatory postsynaptic currents (EPSCs) in mf-CA3 synapse in mice treated with H.
The propofol-induced changes in excitatory postsynaptic currents (EPSCs) and evoked EPSCs resulted from presynaptic GABA[sub]A receptor-mediated depolarization.[sup][11]
Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded under voltage-clamp at -70 mV from CA1 pyramidal neurons after blocking the GABAA receptors by using 30 [micro]M bicuculline.
In a subsequent study, using whole cell recording from lumbar motoneurons, it was demonstrated that both AMPA and NMDA receptor-mediated excitatory postsynaptic currents were rapidly increased following bath application of TNF-[alpha] [115].
Abbreviations: NMJ: neuromuscular junction; CNS: central nervous system; mEPSCs: miniature excitatory postsynaptic currents; VGCC: voltage-gated calcium channel; p: release probability; GPCR: GTP-binding protein coupled receptors; PIP2: phosphatidylinositol-4,5-bisphosphate; AP: action potential.
Cochlear synaptic ribbon pairs consist of presynaptic ribbons, to which many synaptic vesicles are connected, and postsynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), which are glutamate receptors that mediate the excitatory postsynaptic currents of the SGNs' afferent dendrites [2].
However, in contrast to [Tsc1.sup.PC], in which PC postsynaptic currents were intact, in [Pten.sup.PC] mice, the excitatory postsynaptic currents (EPSCs) evoked by PF activity (PF-EPSCs) were aberrantly larger and those evoked by CF activity (CF-EPSCs) were smaller than in controls.
In hippocampal neurons of APP overexpressing transgenic mice, AMPAR-mediated excitatory postsynaptic currents are also significantly decreased [23].
In addition, rare spontaneous or miniature P2X-mediated excitatory postsynaptic currents were recorded at central synapses conveying the idea that ATP and postsynaptic P2X receptors do not act primarily as fast excitatory neurotransmitter at brain synapses [12] and, thus, despite the detection of several P2X subunits at the postsynaptic sites of glutamatergic synapses [15].
AMPA receptor-mediated miniature excitatory postsynaptic currents were isolated pharmacologically with 1 [micro]M tetrodotoxin (TTX), 20 [micro]M bicuculline, and 100 [micro]M DL-2-amino-5 phosphonopentanoic acid (DL-APV).
Incubation with TNF[alpha] increases the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) in lamina II excitatory interneurons [60].
Spontaneous excitatory postsynaptic currents (sEPSCs) were counted and analyzed using the Mini-Analysis program (Synaptosoft, Inc., Decatur, GA, USA) as described previously [25].