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XPOExpress Persistent Objects (Microsoft)
XPOExpress Persistent Objects
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References in periodicals archive ?
4] Nonstandard abbreviations: PSA, prostate specific antigen; miRNA, microRNA; primiRNA, primary miRNA; pre-miRNA, precursor miRNA; dsRNA, double stranded RNA; DGCR8, dsRNA-binding protein of DiGeorge Syndrome Critical Region Gene 8; EXP5, exportin 5; RISC, RNA induced silencing complex; AGO, argonaute protein; TUTase, terminal uridylyl transferase; ac-pre-miR-451, AGO-cleaved pre-miR-451; PARN, poly(A)-specific ribonuclease; TUT, terminal uridyl transferase; [m.
Lund E, Dahlberg JE (2006) Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs.
After its formation, the pre-miRNA is actively transported from the nucleus to the cytoplasm by the Ran-GTP-dependent transporter Exportin 5 (Exp 5) [15,16].
In the nucleus, miRNAs are transcribed as primary pri-miRNA transcripts, and then they are processed to shape the precursor pre-miRNA stem loop structure and then is transported to the cytoplasm by RanGTP and Exportin 5 where they are cleaved by the Dicer RNAase III endonuclease and produce mature miRNA (21-23 nt) (11).