Previous studies in our lab have shown that
F6P but not M6P under hypoxic conditions is capable of decreasing HIF-1[alpha] and CTGF, suggesting M6P has a mechanism of action unrelated to isomerization to
F6P.
Genetic morphism in the glucokinase regulatory protein, which binds to glucokinase and inhibits its activity in the presence of fructose-6-phosphate (
F6P) is associated with ethnicity and may be responsible for different response rates to obesity and diabetes in different populations [96].
Operating in glycolysis, PGI enzyme catalyzes the reversible isomerization from G6P to
F6P (MANCHENKO, 2000; TAIZ; ZEIGER, 2004).