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Previous studies in our lab have shown that F6P but not M6P under hypoxic conditions is capable of decreasing HIF-1[alpha] and CTGF, suggesting M6P has a mechanism of action unrelated to isomerization to F6P.
Genetic morphism in the glucokinase regulatory protein, which binds to glucokinase and inhibits its activity in the presence of fructose-6-phosphate (F6P) is associated with ethnicity and may be responsible for different response rates to obesity and diabetes in different populations [96].
Operating in glycolysis, PGI enzyme catalyzes the reversible isomerization from G6P to F6P (MANCHENKO, 2000; TAIZ; ZEIGER, 2004).