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The effects of FAAH C385A can depend on its interaction with other SNPs.
The FAAH gene is well-known to pain researchers, as it is involved in endocannabinoid signalling which is central to pain sensation, mood and memory.
Scientists have found mice that do not have the FAAH gene have reduced pain sensation, accelerated wound healing, enhanced fear-extinction memory and reduced anxiety.
When significant amounts of phytocannabinoids, such as CBD, are consumed, the FAAH will be used to break them down, instead of breaking down the endocannabinoids.
(13) Furthermore, CBD regulates the activity of FAAH, an enzyme involved in gastrointestinal motility through its actions on anandamide.
In addition to their article, we found that selective FAAH inhibition and dual FAAH/MAGL inhibition produced profound analgesic effect; however, selective MAGL inhibition was not effective in colorectal distension-induced visceral pain model (5).
Of note, some of such associations are reported for the first time, except for rs1799883 (FABP2) , rs660339 (UCP2) and rs659366 (UCP2) , rs1052700 (PLIN1) , rs17782313 (MC4R) , rs7799039 (LEP) , rs2943641 (IRS1) , rs9939609 (FTO) , and rs324420 (FAAH) .
Taking into consideration that FAAH and MGL degrade the endocannabinoids, their inhibitors have been evaluated in animal models of CINP.
Endocannabinoids are internalized by a selective transporter and degraded by specific enzymes (FAAH, MAGL) (32).
Pasteris, Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.
An increase in the liberation of endocannabinoids is associated with the anxiolytic effect, which has driven the development of many pharmaceuticals, especially those linked to the blockade of endocannabinoid degrading enzymes FAAH and MAGL (Gaetani et al., 2003; Kinsey et al., 2011).
Fatty acid amidohydrolase (FAAH) is the most widely studied element in the process of cannabinergic inactivation (Maccarrone & Finazzi-Agro, 2004).
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