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In this regard, differential regulation of delta 4-desaturase, sphingolipid 1 (DEGSJ) and fatty acid binding protein 3 (FABP3) in hippocampus and lipid phosphate phos-phatase-related protein type 4 (LPPR4) in temporal cortex datasets may fairly explain the relationship between brain damages happening in these regions and lipid metabolism.
Carullo et al., "The circulating level of FABP3 is an indirect biomarker of microRNA-1," Journal of the American College of Cardiology, vol.
ACSS1, ACSS2, ADFP, CD36, FABP3, FASN, GPAM, INSIG1, LPL, SCD5, SPTLC1, SREBF1, and XDH had higher mammary expression over skin or muscle; ADFP, FASN, GPAM, LPL, SREBF1, and XDH showed preferential expression during adulthood and, hence, was considered most likely to be differentially expressed during milk fat synthesis.
Gene name Protein name Average t-test ratio 1 PDIA3 Protein disulfide- 1,5 0,011 isomerase A3 precursor 2 VIM Vimentin 1,8 0,007 3 SELENBP1 Selenium-binding 1,3 0,044 protein 1 4 ENO1 Alpha-enolase 1,4 0,007 5 EIF2S1 Eukaryotic -1,6 0,035 translation initiation factor 2 subunit 1 6 CAPZA1 F-actin capping 1,3 0,028 protein subunit alpha-1 7 PSMA3 Proteasome subunit -1,2 0,026 alpha type 3 8 RPSA 40S ribosomal -1,4 0,023 protein SA 9 ERP29 Endoplasmic 1,4 0,040 reticulum protein ERp29 10 TPI1 Triosephosphate 1,7 0,00009 isomerase 11 PARK7 Protein DJ-1 1,2 0,018 12 tubb Tubulin beta chain -1,7 0,017 13 TUBA1B Tubulin alpha-1B chain -1,9 0,006 14 FABP3 Fatty acid-binding 2,2 0,00035 protein, heart A selection of proteins differentially expressed between primary UM with and without metastasis.
One pathway is under direct regulation of PPAR[gamma] and encompasses genes such as LPL, NR1H3, and FABP3 (Figures 6(b) and 6(e)); another is under indirect regulation of PPAR[gamma] through SREBF1 and NR1H3 (Figure 6(e)) which would, in turn, participate in upregulation of the transcription of FASN and ACACA [23-25].
FABP3 expression was slightly higher in T1 and T3 groups and slightly lower in the T2 group compared with the control(p = 0.05).
Fabp3 is not expressed in the embryonic brain and in the adult NSPCs , suggesting no function in NSPCs.
The antibodies in human FABP4 ELISA are highly specific for human FABP4, with no detectable cross-reactivity to human FABP1, FABP2, FABP3, or FABP5.
The QTL for C17:1, C18:1, C18:2, C20:4, MUFA, and PUFA maps to a region containing the fatty acid binding protein 3 (FABP3) gene on SSC6 .
The expression levels of 10 genes: retinoid X receptor alpha (RXRA), peroxisome proliferator-activated receptor gamma (PPARG), phospholipid transfer protein (PLTP), stearoylCoA desaturase (SCD), nuclear receptor subfamily 1 group H member 3 (NR1H3), fatty acid binding protein 3 (FABP3), carnitine palmitoyltransferase II (CPT2), acyl-Coenzyme A dehydrogenase long chain (ACADL), acyl-Coenzyme A oxidase 2 branched chain (ACOX2), and fatty acid binding protein 4 (FABP4), showed significant differences in gene expression between the low- and high-marbled groups (p < 0.05) (Table 2).
Bionaz and Loor (2008) reported that peroxisome proliferator-activated receptor gamma (PPARG) which is one of members of the nuclear receptor transcription factors was up-regulated and the expression of genes involved in de novo fatty acid synthesis (acetylcoenzyme A carboxylase alpha (ACACA) and fatty acid synthase (FASN), fatty acid uptake and transport (Cluster of differentiation 36 (CD36) and Fatty acid-binding protein 3 (FABP3)) and desaturation (Stearoyl-CoA desaturase [SCD]) was stimulated during lactation (Bionaz and Loor, 2008b).
Several genes expressed in the muscle may be involved in the function of TZD, including PPARy coactivator 1 (PGC-1), glucose transporter 4 (GLUT4) and fatty acid-binding protein 3 (FABP3) (Wu et al., 2010; Li et al., 2011b).
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