However, it has been also observed that retinoic acid favours binding to PPAR[beta]/[gamma], which in turn can induce anti-apoptotic and proliferative responses only when
FABP5 concentration becomes higher [6].
co-expressed, adipocyte--A-FABP (FABP4), epidermal--E-FABP (
FABP5),
granzyme B; G protein coupled R 65), as well as genes involved in increasing lipid and steroid metabolism, for example phospholipase A2 and fatty acid binding protein 5 (
FABP5).
Of the up-regulated genes,
FABP5, PLIN4, and phosphoenolpyruvate carboxykinase 1 (PCK1) were increased in both TPP- and IPTP-treated cells.
Of the fatty acid binding proteins (FABPs) present in mammalian tissues, FABP4 and cutaneous FABP (
FABP5) have been extensively studied in prostate cancer.