FAMMMFamilial Atypical Multiple Mole Melanoma
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Koorstra et al., NM NM History of 2008 [45] alcoholic pancreatitis P16 Leiden mutation (FAMMM syndrome) 8.
[8] Nonstandard abbreviations: PC, pancreatic cancer; CT, computed tomography; MRI, magnetic resonance imaging; ERCP, endoscopic retrograde cholangiopan-creatography; CA19.9, carbohydrate antigen 19.9; FAMMM, familial atypical multiple mole melanoma; HNPCC, hereditary nonpolyposis colorectal cancer; MRCP, magnetic resonance cholangiopancreatography; FDA, US Food and Drug Administration; EGTM, European Group on Tumor Markers.
The present study has evaluated endoscopic ultrasound (EUS) for screening in high-risk individuals: 13 with FAMMM families, 21 with familial pancreatic cancer, three with hereditary pancreatitis, two with Peutz-Jeghers syndrome, five with BRCA1 and BRCA2 mutations and one Li-Fraumeni syndrome.
CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families.
Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome.
Familial atypical multiple mole melanoma (FAMMM) is an autosomal dominant inherited syndrome with incomplete penetrance.
Although many reports have described the association of pancreatic carcinoma with FAMMM, no unique histopathologic features have been reported for the pancreatic cancers that develop in patients with FAMMM.