FANCG


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Related to FANCG: fancy, FANCC, FANCA
AcronymDefinition
FANCGFanconi Anemia, Complementation Group G
References in periodicals archive ?
There does not appear to be a significantly increased risk of cancer in carriers of mutations in the more common FA genes, including FANCA, FANCC and FANCG, [37] but larger studies are required to clarify this.
Testing is offered for the common founder Ashkenazi Jewish mutation in the FANCC gene, for three founder mutations in the FANCA gene in the Afrikaner population, and for the seven base-pair deletion mutation in the FANCG gene in black SA patients (F Essop, personal communication, May 2017).
Descriptive comparisons were also made with the previously published data on the physical phenotypic characteristics in black South African patients with FA caused by a homozygous FANCG founder mutation.
A common 7 base pair deletion founder mutation (c.637643delTACCGCC) in the FANCG gene has been found in the homozygous state in 77.5% (31/40) of South African black patients and in a further 5% (2/40) of patients in the heterozygous state.
Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1.
The genes of the Fanconi anemia pathway involved in pancreatic tumorigenesis include the FANCC and FANCG genes and most notably the BRCA2 gene.