En 1955 la FAOD paso a tener sede propia en la Rua da Gloria con una policlinica con 15 equipos, una sala con 5 equipos de ortodoncia y odontopediatria, consultorios mas modernos con aparatos de Rayos X y 3 salas para clases y conferencias.
En los anos que siguieron la FAOD paso por periodos de estructuracion fisica y administrativa.
The company plans to initiate a Phase 2 clinical trial with UX007 later this year in patients with long-chain FAOD. The company is also completing a retrospective study of triheptanoin in 24 long-chain FAOD patients who have been receiving triheptanoin through an investigator-sponsored compassionate-use protocol for up to 13 years.
In addition to advancing its own development program toward potential approval, Ultragenyx is supporting multiple independent investigator-sponsored and compassionate-use clinical trials in FAOD and other indications and is providing drug free of charge for these studies.
Several thousand patients are afflicted with FAOD in the U.S.
UX007 is planned to enter Phase 2 clinical trials for long-chain FAOD later this year.
Reagent 3 was composed of 26 kU/L FAOD (ARKRAY) (14-16); 78 kU/L POD (Kikkoman); 0.08 mmol/L N-(carboxymethyl-aminocarbonyl)-4,4'-bis(dimethylamine)-diphenylamine, sodium salt (DA-64; Wako Pure Chemical Industries, Ltd.); and 300 mmol/L Tris-HCl.
FAOD produced [H.sub.2][O.sub.2] from fructosyl amino acid.
The second technical advance is the development of FAOD, which reacts only with the fructosyl amino acid generated by the specific protease.
We thank for Nobuo Kato and Yasuyoshi Sakai (Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University) and Yoshiki Tani and Nobuyuki Yoshida (Graduate School of Biological Science, Nara Institute of Science and Technology), who collaborated in the research and development of FAOD.