FCGR2AFc Fragment of Igg, Low Affinity IIa, Receptor for
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Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis.
4] Human genes: GALC, galactosylceramidase; ACADM, acyl-CoA dehydrogenase, C-4 to C-12 straight chain; ACADVL, acyl-CoA dehydrogenase, very long chain; GALT, galactose-1-phosphate uridyl transferase; PAH, phenylalanine hydroxylase; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); RPP30, ribonuclease P/MRP 30kDa subunit.
A relationship between common functional genetic polymorphisms of the low-affinity Fc gamma receptor genes, FCGR2A, -3A, and -3B, and the risk of cryptococcosis in HIV-uninfected patients was recently reported (33).
FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab.
Nine candidates failed the initial criteria, such as assay length or unsuitable CpG site location for primer and probe placement [BCOR, BCL6 co-repressor; CAV1, caveolin 1, caveolae protein, 22kDa; CD44, CD44 molecule (Indian blood group); CDH13, cadherin 13, H-cadherin (heart); VCAN (formerly CSPG2), versican; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); GSK3B, glycogen synthase kinase 3 beta; PCDH17, protocadherin 17; and TAF11, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa].
In that study, 55 children with recurrent infections were evaluated for several factors of the immune system: IgG, IgA, IgM, and IgG subclass concentrations; MBL2 genotype; IgG2 subclass allotype (GM); partial C4 and C2 deficiency; FCGR2A [Fc fragment of IgG, low affinity IIa, receptor (CD32)] polymorphism; and the specific antibody response to the pneumococcal vaccine Pneumovax.