FCGR2AFc Fragment of Igg, Low Affinity IIa, Receptor for
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Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis.
[4] Human genes: GALC, galactosylceramidase; ACADM, acyl-CoA dehydrogenase, C-4 to C-12 straight chain; ACADVL, acyl-CoA dehydrogenase, very long chain; GALT, galactose-1-phosphate uridyl transferase; PAH, phenylalanine hydroxylase; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); RPP30, ribonuclease P/MRP 30kDa subunit.
(16) investigated polymorphisms of Fc[gamma] receptor 2A (FCGR2A) and CRP including -717A>G, -286C>T>A, +1059G>C, +1444C>T and +1846G>A and their effects on CIMT in 2260 young adults.
A relationship between common functional genetic polymorphisms of the low-affinity Fc gamma receptor genes, FCGR2A, -3A, and -3B, and the risk of cryptococcosis in HIV-uninfected patients was recently reported (33).
Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients.
FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab.
Previous GWASs have confirmed that several loci confer susceptibility to KD, including single-nucleotide polymorphisms (SNPs) in the BLK [12,13], FCGR2A [14,15], ITPKC [14, 16], and CASP3 [17, 18].
Another GWAS and replication analysis of five independent sample populations collected from around the world that included 2173 individuals with KD and 9383 controls found that the FCGR2A gene was associated with higher susceptibility to KD [14].
Nine candidates failed the initial criteria, such as assay length or unsuitable CpG site location for primer and probe placement [BCOR, BCL6 co-repressor; CAV1, caveolin 1, caveolae protein, 22kDa; CD44, CD44 molecule (Indian blood group); CDH13, cadherin 13, H-cadherin (heart); VCAN (formerly CSPG2), versican; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); GSK3B, glycogen synthase kinase 3 beta; PCDH17, protocadherin 17; and TAF11, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa].
In that study, 55 children with recurrent infections were evaluated for several factors of the immune system: IgG, IgA, IgM, and IgG subclass concentrations; MBL2 genotype; IgG2 subclass allotype (GM); partial C4 and C2 deficiency; FCGR2A [Fc fragment of IgG, low affinity IIa, receptor (CD32)] polymorphism; and the specific antibody response to the pneumococcal vaccine Pneumovax.