Typically, therapeutic mAbs are of the IfG isotype and so Fc gamma Receptors (FcyRs
) are centrally involved in their regulation and mode of action.
La explicacion a dicho evento esta asociada con el estimulo generado por la fosforilacion del dominio intracitoplasmatico de FcyR
por la quinasa Syk en pacientes con LES, lo cual induce un incremento en la concentracion de calcio ([Ca.sup.+.sub.2]) citoplasmatico, lo cual activa la actividad fosfatasa de la calcineurina sobre el NFAT.
family includes major CRP targets, expressed in numerous cells of the immune system, controlling activation, proliferation, phagocytosis, degranulation, and cytokine secretion , thus regulating local inflammatory processes, such as those occurring in atherosclerotic plaques.
Perhaps an effect amplifying the hypothesized mechanisms proposed is the influence of FcyR
polymorphisms on the response to IVIG therapy.
Following manual counting by trypan blue exclusion, cells were washed and incubated for 20 minutes on ice with FcyR
Block (2.4G2 clone) and for 30 minutes with the following antibodies: APC-conjugated hamster anti-mouse CD11c, PE-CD80, -CD86, -CD11b, FITC-hamster anti-mouse CD40, PerCPCy5.5-anti-MHC class II, and PeCy7-anti-Gr-1, which stains Ly6C and Ly6G.
Oxenius, "Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcyR
or complement," European Journal of Immunology, vol.
expression on NK cells influences disease severity in rheumatoid arthritis," Genes and Immunity, vol.
Targan, "The T cell costimulator TL1A is induced by FcyR
signaling in human monocytes and dendritic cells," Journal of Immunology, vol.
Bouaziz et al., "B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in FcyR
effector functions," The Journal of Immunology, vol.